You bet!
Knives, like prox mines, weren't compatible with the infinite ammo cheat, since with that cheat you couldn't interact with the ammo boxes AT ALL, and hence never actually get the weapons.
So that was annoying.
We would typically play knives on at least -2 health or lower, since otherwise it took forever to play out.
PS: I'm telling you; we tried everything. We done played that game out!